Simple Blood Test May Predict Faster Alzheimer’s Decline, Study Finds

Simple Blood Test May Predict Faster Alzheimer’s Decline, Study Finds
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Researchers estimate about 69 million people globally are living with early-stage Alzheimer’s disease, which begins with mild cognitive impairment. Detecting Alzheimer’s early can help slow its progression with existing treatments and lifestyle changes, but predicting how quickly it will advance remains challenging.

A new study presented at the European Academy of Neurology Congress 2025 suggests that a simple blood test known as the TyG index — commonly used to measure insulin resistance — could help identify people with early Alzheimer’s who are at higher risk of rapid cognitive decline.

The study followed 315 older adults without diabetes for three years. Results showed that participants with higher TyG index scores were four times more likely to experience faster memory and cognitive deterioration than those with lower scores.

Researchers say the TyG index, which combines common triglyceride and glucose measures, could be an affordable way to guide early, personalized interventions. Experts believe it may help doctors target high-risk patients for closer monitoring, lifestyle changes, or clinical trials.

The findings have not yet been peer-reviewed. Researchers are now exploring whether the TyG index aligns with brain imaging results, aiming to refine Alzheimer’s risk models and improve treatment strategies for millions affected worldwide.