Scientists Discover Method to Revert Cancer Cells to Normal State

Scientists Discover Method to Revert Cancer Cells to Normal State
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Researchers at the Korea Advanced Institute of Science and Technology (KAIST) have developed a groundbreaking method, called REVERT, that can potentially transform cancer cells back into normal, healthy cells, Earth.com reported. This innovative approach shifts the focus from destroying malignant cells to reprogramming them, offering a new strategy for cancer treatment.

REVERT works by analyzing a cancer cell’s gene activity to identify a “molecular switch” capable of reversing its cancerous behavior. By manipulating specific genes, such as MYC and YY1 in colorectal cancer, scientists observed malignant cells returning to a normal state. Further tests using patient-derived colon organoids showed that targeting another gene, USP7, also restored orderly cell structure.

This discovery holds significant promise for reducing the harsh side effects associated with traditional cancer therapies like chemotherapy and radiation, potentially making treatment more tolerable, especially for vulnerable patients. While still a laboratory concept, the REVERT method not only provides a deeper understanding of cancer’s genetic changes but also opens new avenues for personalized cancer treatments and applications in regenerative medicine.