Men face dramatically increased risk of dementia due to common genetic mutation
Men face dramatically increased risk of dementia due to common genetic mutation
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A common genetic mutation in the HFE gene, known as H63D, significantly increases the risk of dementia in men, Earth.com reported based on a new study analyzing nearly 12,200 Australians and Americans.
About one in 36 men carries two copies of this mutation, which more than doubles their chances of developing dementia. The HFE gene regulates iron in the body, and the H63D variant can disrupt iron balance in brain cells, leading to oxidative stress and inflammation linked to Alzheimer’s disease.
The ASPREE trial, which followed over 19,000 healthy seniors for 6.4 years, found that men with two H63D copies had a 2.39 times higher risk of dementia, while women with the same mutation showed no increased risk. Researchers suggest that women’s natural iron loss through menstruation and protective effects of estrogen may reduce their vulnerability.
Experts recommend broader genetic screening for aging men to identify those at risk early. While no direct link was found between blood iron levels and dementia, maintaining normal iron, treating inflammation, staying active, and a plant-based diet support brain health. The study highlights the potential for sex-specific prevention strategies in dementia care.
