Ancient DNA Study Traces Origins of Human Pathogens to 6,500 Years Ago

Ancient DNA Study Traces Origins of Human Pathogens to 6,500 Years Ago
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A groundbreaking study led by Professor Eske Willerslev from the Universities of Copenhagen and Cambridge has identified DNA from 214 known human pathogens in prehistoric remains across Eurasia, according to findings published in Nature.

Analyzing samples from over 1,300 individuals—some dating back 37,000 years—the research provides the earliest genetic evidence of zoonotic diseases, with the first cases appearing around 6,500 years ago and becoming more widespread about 5,000 years ago.

The study links the rise of infectious diseases to the advent of farming, animal domestication, and large-scale human migrations. Researchers suggest such infections may have shaped ancient population movements and genetic evolution.

The findings may inform future vaccine development by highlighting recurring mutations in disease-causing microbes. Understanding how pathogens evolved in the past could aid in anticipating and managing future outbreaks, particularly those of animal origin.