Scientists Uncover Protein Secrets Behind Longevity in Mammals

Researchers at Bar-Ilan University have identified key protein modifications linked to healthy aging across 107 mammalian species, from short-lived rodents to century-old whales, SciTech Daily reported.

Published in Nature Communications, the study used a novel computational tool, PHARAOH, to analyze evolutionary patterns in posttranslational modifications (PTMs) like acetylation. These PTMs regulate cellular processes and are enriched in long-lived species, offering protection against cancer and neurodegenerative diseases.

Led by Prof. Haim Cohen, the team found that large mammals (e.g., whales) exhibit fewer cancers despite having more cells—a phenomenon tied to specific PTMs. The findings suggest nature’s blueprint for longevity could inspire therapies mimicking these mechanisms to extend human healthspan.

The study underscores evolution as a guide for future anti-aging research, with potential applications for cancer, Alzheimer’s, and diabetes.