Researchers at the University of California, San Diego School of Medicine have identified a promising new drug, lorundrostat, for treating resistant or uncontrolled high blood pressure. In a recent Phase II clinical trial involving 285 participants, lorundrostat demonstrated significant efficacy by reducing systolic blood pressure by an average of 15 points, compared to a 7-point reduction in those receiving a placebo.<\/p>\n\n\n\n
Hypertension, commonly known as high blood pressure, affects nearly half of all adults in the United States and remains a leading cause of heart disease. The hormone aldosterone plays a critical role in regulating blood pressure, and its dysregulation is often linked to treatment-resistant hypertension. Lorundrostat works by inhibiting aldosterone production, addressing an underrecognized cause of high blood pressure.<\/p>\n\n\n\n
During the 12-week trial, all participants received standardized antihypertensive medication, with 190 patients additionally receiving lorundrostat and 95 receiving a placebo. Blood pressure was monitored continuously, revealing that lorundrostat significantly lowered systolic levels in patients who had previously struggled to control their hypertension.<\/p>\n\n\n\n
The study\u2019s principal investigator, Dr. Michael Wilkinson, emphasized the potential of lorundrostat as an important new tool for managing high blood pressure. The research team plans to advance to a larger Phase III trial to further assess the drug\u2019s safety and effectiveness across a diverse patient population.<\/p>\n\n\n\n
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Researchers at the University of California, San Diego School of Medicine have identified a promising new drug, lorundrostat, for treating resistant or uncontrolled high blood pressure. In a recent Phase II clinical trial involving 285 participants, lorundrostat demonstrated significant efficacy by reducing systolic blood pressure by an average of 15 points, compared to a 7-point …<\/p>\n","protected":false},"author":33,"featured_media":124558,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"rop_custom_images_group":[],"rop_custom_messages_group":[],"rop_publish_now":"yes","rop_publish_now_accounts":{"facebook_108372464460192_245495985553329":""},"rop_publish_now_history":[],"rop_publish_now_status":"pending","footnotes":""},"categories":[8955],"tags":[14313],"class_list":["post-124532","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medical-news","tag-hypertension-drug"],"yoast_head":"\n