{"id":114757,"date":"2024-11-28T03:45:00","date_gmt":"2024-11-28T00:45:00","guid":{"rendered":"https:\/\/shiawaves.com\/english\/?p=114757"},"modified":"2024-11-28T03:17:35","modified_gmt":"2024-11-28T00:17:35","slug":"scientists-identify-hidden-rna-structure-that-triggers-parkinsons-disease","status":"publish","type":"post","link":"https:\/\/shiawaves.com\/english\/uncategorized\/114757-scientists-identify-hidden-rna-structure-that-triggers-parkinsons-disease\/","title":{"rendered":"Scientists Identify Hidden RNA Structure That Triggers Parkinson\u2019s Disease"},"content":{"rendered":"\n<p>Researchers at Kumamoto University have unveiled a significant mechanism behind the aggregation of proteins linked to neurodegenerative diseases, particularly Parkinson\u2019s Disease, SciTech Daily revealed yesterday.<\/p>\n\n\n\n<p>Led by Professor Norifumi Shioda and Associate Professor Yasushi Yabuki, the team discovered that G-quadruplexes (G4s), unique RNA structures, play a crucial role in promoting the harmful aggregation of \u03b1-synuclein, a protein associated with neurodegeneration.<\/p>\n\n\n\n<p>The study revealed that elevated intracellular calcium ions (Ca\u00b2\u207a) due to cellular stress trigger the assembly of G4s, which then attract \u03b1-synuclein, leading to its aggregation and subsequent neuronal damage. Remarkably, treatment with 5-aminolevulinic acid (5-ALA), a compound that inhibits G4 formation, successfully prevented \u03b1-synuclein aggregation and halted the progression of Parkinson\u2019s-like symptoms in mice.<\/p>\n\n\n\n<p>This groundbreaking research highlights G4s as a potential therapeutic target, opening avenues for early intervention in Parkinson\u2019s and possibly other neurodegenerative diseases.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers at Kumamoto University have unveiled a significant mechanism behind the aggregation of proteins linked to neurodegenerative diseases, particularly Parkinson\u2019s Disease, SciTech Daily revealed yesterday. Led by Professor Norifumi Shioda and Associate Professor Yasushi Yabuki, the team discovered that G-quadruplexes (G4s), unique RNA structures, play a crucial role in promoting the harmful aggregation of \u03b1-synuclein, &hellip;<\/p>\n","protected":false},"author":33,"featured_media":114758,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"rop_custom_images_group":[],"rop_custom_messages_group":[],"rop_publish_now":"initial","rop_publish_now_accounts":{"facebook_108372464460192_245495985553329":""},"rop_publish_now_history":[],"rop_publish_now_status":"pending","footnotes":""},"categories":[1],"tags":[],"class_list":["post-114757","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.3 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Scientists Identify Hidden RNA Structure That Triggers Parkinson\u2019s Disease - Shia Waves<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/shiawaves.com\/english\/uncategorized\/114757-scientists-identify-hidden-rna-structure-that-triggers-parkinsons-disease\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Scientists Identify Hidden RNA Structure That Triggers Parkinson\u2019s Disease - Shia Waves\" \/>\n<meta property=\"og:description\" content=\"Researchers at Kumamoto University have unveiled a significant mechanism behind the aggregation of proteins linked to neurodegenerative diseases, particularly Parkinson\u2019s Disease, SciTech Daily revealed yesterday. Led by Professor Norifumi Shioda and Associate Professor Yasushi Yabuki, the team discovered that G-quadruplexes (G4s), unique RNA structures, play a crucial role in promoting the harmful aggregation of \u03b1-synuclein, &hellip;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/shiawaves.com\/english\/uncategorized\/114757-scientists-identify-hidden-rna-structure-that-triggers-parkinsons-disease\/\" \/>\n<meta property=\"og:site_name\" content=\"Shia Waves\" \/>\n<meta property=\"article:published_time\" content=\"2024-11-28T00:45:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-11-28T00:17:35+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/shiawaves.com\/english\/wp-content\/uploads\/sites\/4\/2024\/11\/Screenshot-2024-11-28-030843.png\" \/>\n\t<meta property=\"og:image:width\" content=\"907\" \/>\n\t<meta property=\"og:image:height\" content=\"596\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Rathaei\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Rathaei\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/shiawaves.com\/english\/uncategorized\/114757-scientists-identify-hidden-rna-structure-that-triggers-parkinsons-disease\/\",\"url\":\"https:\/\/shiawaves.com\/english\/uncategorized\/114757-scientists-identify-hidden-rna-structure-that-triggers-parkinsons-disease\/\",\"name\":\"Scientists Identify Hidden RNA Structure That Triggers Parkinson\u2019s Disease - 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